Similar Items

Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2

Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2

Following a structure-based virtual screening, a series of 2,4 thiazolidinediones was synthesized in order to explore structure activity relationships for inhibition of the Plasmodium falciparum cysteine protease falcipain-2 (FP-2) and of whole cell antiparasitic activity. Most compounds exhibited l...

Full description

Saved in:
Bibliographic Details
Main Authors: Sharma, Rajni Kant, Younis, Yassir, Mugumbate, Grace, Njoroge, Mathew, Gut, Jiri, Rosenthal, Philip J, Chibale, Kelly
Format: Article
Language:English
Published: Elsevier 2022
Subjects:
Antiplasmodial agents
Falcipain-2
Thiazolidinone
Online Access:https://doi.org/10.1016/j.ejmech.2014.11.061
http://hdl.handle.net/11408/4923
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1016/j.ejmech.2014.11.061
http://hdl.handle.net/11408/4923