Novel anti-Plasmodial hits identified by virtual screening of the ZINC database

Increased resistance of Plasmodium falciparum to most available drugs challenges the control of malaria. Studies with protease inhibitors have suggested important roles for the falcipain family of cysteine proteases. These enzymes act in concert with other proteases to hydrolyze host erythrocyte hem...

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Bibliographic Details
Main Authors: Mugumbate, Grace, Newton, Ana S., Rosenthal, Philip J., Gut, Jiri, Moreira, Rui, Chibale, Kelly, Guedes, Rita C.
Format: Article
Language:English
Published: Springer 2022
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Online Access:https://doi.org/10.1007/s10822-013-9685-z
http://hdl.handle.net/11408/4921
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