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Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

High-throughput phenotypic screens have re-emerged as screening tools in antibiotic discovery. The advent of such technologies has rapidly accelerated the identification of 'hit' compounds. A pre-requisite to medicinal chemistry optimisation programmes required to improve the drug-like pro...

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Bibliographic Details
Main Authors: Cox, Jonathan A G, Mugumbate, Grace, Peral, Laura Vela-Glez Del, Jankute, Monika, Abrahams, Katherine A, Jervis, Peter, Jackenkroll, Stefan, Perez, Arancha, Alemparte, Carlos, Esquivias, Jorge, Lelièvre, Joël, Ramon, Fernando, Barros, David, Ballell, Lluis, Besra, Gurdyal S
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
Antibiotics
High-throughput screening
Phenotypic screening
Target validation
Online Access:https://www.nature.com/articles/srep38986
http://hdl.handle.net/11408/4905
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https://www.nature.com/articles/srep38986
http://hdl.handle.net/11408/4905