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Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach

Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach

Mycobacterium phenotypic hits are a good reservoir for new chemotypes for the treatment of tuberculosis. However, the absence of defined molecular targets and modes of action could lead to failure in drug development. Therefore, a combination of ligand-based and structure-based chemogenomic approach...

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Main Authors: Mugumbate, Grace, Mendes, Vitor, Blaszczyk, Michal, Sabbah, Mohamad, Papadatos, George, Lelievre, Joel, Ballell, Lluis, Barros, David, Abell, Chris, Blundell, Tom L., Overington, John P.
Format: Article
Language:English
Published: Frontiers in Pharmacology 2022
Subjects:
Mycobacterium tuberculosis,
Phenotypic hits,
Target identification,
Drug resistance,
EthR,
InhA
Online Access:https://doi.org/1https://doi.org/10.3389/fphar.2017.006810.3389/fphar.2017.00681
http://hdl.handle.net/11408/4904
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https://doi.org/1https://doi.org/10.3389/fphar.2017.006810.3389/fphar.2017.00681
http://hdl.handle.net/11408/4904