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Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation

Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation

The lack of success in target-based screening approaches to the discovery of antibacterial agents has led to reemergence of phenotypic screening as a successful approach of identifying bioactive, antibacterial compounds. A challenge though with this route is then to identify the molecular target(s)...

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Bibliographic Details
Main Authors: Mugumbate, Grace, Abrahams, Katherine A., Cox, Jonathan A. G., Papadatos, George, Westen, Gerard van, Lelièvre, Joël, Calus, Szymon T., Loman, Nicholas J., Ballell, Lluis, Barros, David, Overington, John P., Besra, Gurdyal S.
Format: Article
Language:English
Published: Public Library of Science 2022
Subjects:
Mycobacterium tuberculosis
Mycobacterium bovis
Tuberculosis drug discovery
Drug interactions
Crystal structure
Online Access:https://doi.org/10.1371/journal.pone.0121492
http://hdl.handle.net/11408/4895
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https://doi.org/10.1371/journal.pone.0121492
http://hdl.handle.net/11408/4895