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Computational Deorphaning of Mycobacterium tuberculosis Targets

Computational Deorphaning of Mycobacterium tuberculosis Targets

Tuberculosis (TB) continues to be a major health hazard worldwide due to the resurgence of drug discovery strains of Mycobacterium tuberculosis (Mtb) and co-infection. For decades drug discovery has concentrated on identifying ligands for ~10 Mtb targets, hence most of the identified essential prote...

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Bibliographic Details
Main Authors: Bishi, Lorraine Yamurai, Vedithi, Sundeep Chaitanya, Blundell, Tom L., Mugumbate, Grace Chitima
Format: Book chapter
Language:English
Published: IntechOpen 2022
Subjects:
Mycobacterium tuberculosis
target deorphaning
target deconvolution
proteome modelling
virtual screening
Online Access:http://hdl.handle.net/11408/4894
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http://hdl.handle.net/11408/4894