Effect of Schistosoma haematobium infection on the cognitive functions of preschool age children and benefits of treatment from an endemic area in Zimbabwe
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| Format: | research article |
| Language: | English |
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2023
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| Online Access: | https://cris.library.msu.ac.zw//handle/11408/5388 |
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| author | Arthur Vengesai Maritha Kasambala Takafira Mduluza Tariro Mduluza-Jokonya Luxwell Jokonya Herald Midzi Rutendo Birri Makota Arnold Mutemeri Emmanuel Maziti Bazondlile Dube-Marimbe Dixon Chibanda Francisca Mutapi Samson Mukaratirwa |
| author2 | Midlands State University |
| author_facet | Midlands State University Arthur Vengesai Maritha Kasambala Takafira Mduluza Tariro Mduluza-Jokonya Luxwell Jokonya Herald Midzi Rutendo Birri Makota Arnold Mutemeri Emmanuel Maziti Bazondlile Dube-Marimbe Dixon Chibanda Francisca Mutapi Samson Mukaratirwa |
| author_sort | Arthur Vengesai |
| collection | DSpace |
| description | Abstract |
| format | research article |
| id | ir-11408-5388 |
| institution | My University |
| language | English |
| publishDate | 2023 |
| publisher | BMC [Commercial Publisher] |
| record_format | dspace |
| spelling | ir-11408-53882023-03-06T07:59:55Z Effect of Schistosoma haematobium infection on the cognitive functions of preschool age children and benefits of treatment from an endemic area in Zimbabwe Arthur Vengesai Maritha Kasambala Takafira Mduluza Tariro Mduluza-Jokonya Luxwell Jokonya Herald Midzi Rutendo Birri Makota Arnold Mutemeri Emmanuel Maziti Bazondlile Dube-Marimbe Dixon Chibanda Francisca Mutapi Samson Mukaratirwa Midlands State University School of Life Sciences, University of KwaZulu-Natal, KwaZulu-Natal, Durban, South Africa Department of Biotechnology and Biochemistry, University of Zimbabwe, Mt Pleasant, P.O. Box MP 167, Harare, Zimbabwe Department of Biotechnology and Biochemistry, University of Zimbabwe, Mt Pleasant, P.O. Box MP 167, Harare, Zimbabwe Department of Surgery, College of Health Sciences, University of Zimbabwe, Mt Pleasant, P.O. Box MP 167, Harare, Zimbabwe Department of Biotechnology and Biochemistry, University of Zimbabwe, Mt Pleasant, P.O. Box MP 167, Harare, Zimbabwe Department of Biological Sciences and Ecology, University of Zimbabwe, Mt Pleasant, P.O. Box MP 167, Harare, Zimbabwe Department of Psychiatry, College of Health Sciences, University of Zimbabwe, Mt Pleasant, P.O. Box MP 167, Harare, Zimbabwe Department of Psychiatry, College of Health Sciences, University of Zimbabwe, Mt Pleasant, P.O. Box MP 167, Harare, Zimbabwe Department of Psychiatry, College of Health Sciences, University of Zimbabwe, Mt Pleasant, P.O. Box MP 167, Harare, Zimbabwe Department of Psychiatry, College of Health Sciences, University of Zimbabwe, Mt Pleasant, P.O. Box MP 167, Harare, Zimbabwe Institute for Immunology and Infection Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King’s Buildings, Charlotte Auerbach Rd, EH9 3JT, Edinburgh, UK School of Life Sciences, University of KwaZulu-Natal, KwaZulu-Natal, Durban, South Africa Cognitive functions Early child development Pre-school aged children Schistosomiasis Abstract Abstract Background Schistosomiasis is known to affect the cognitive functions of children, however, but there is paucity of information on its impact on early childhood development in developing countries where the disease is endemic. This study aimed at determining the effects of schistosomiasis due to Schistosoma haematobium on early childhood development in children below 5 years old from Murewa District, Zimbabwe, including the benefits of treatment. Methods Preschool age children (PSAC) under the age of 5 years were screened at baseline and at 6 months post-treatment for S. haematobium infections diagnosed using the urine filtration method. Cognitive domains were assessed using the Griffith Mental Developmental Scales III on 136 PSAC. Multivariate logistic regression was used to determine the level of association between S. haematobium infection and performance in the cognitive domains adjusting for confounding factors (i.e. nutrition, hemoglobin levels, gender and age). Median Development Quotient scores of each cognitive domain at baseline and at 6 months post-treatment were compared and quantified. Results After adjusting for confounding factors, PSAC infected with S. haematobium had greater odds of having lower scores in the Foundation of Learning Domain (OR = 3.9, p = 0.008), Language and Communication Domain (OR = 3.2, p = 0.017), Eye-Hand Coordination Domains (OR = 10.7, p = 0.001), Personal-Social-Emotional Domain (19.3, p = 0.001) and in the Overall General Development Domain (7.2, p = 0.011). Improvement of cognitive performance was observed at 6 months post treatment in the following Domains; Language and Communication Domain (p = 0.003), Eye-Hand Coordination Domain (p = 0.02) and General Development Domain (p = 0.006). Conclusion The study showed that S. haematobium infection in PSAC is associated with lower cognitive scores in the Foundation of Learning, Language and Communication, Eye-Hand Coordination, Personal-Social-Emotional and in the Overall General Development domains. Our results strengthen the call for inclusion of PSAC in routine deworming programs for the control of urinary schistosomiasis and the need to develop locally validated tools to monitor early child development in endemic areas where resources are limited. 22 1 2 9 2023-03-06T07:59:54Z 2023-03-06T07:59:54Z 2022-10-31 research article https://cris.library.msu.ac.zw//handle/11408/5388 DOI:10.1186/s12879-022-07784-7 en BMC Infectious Diseases 1471-2334 open BMC [Commercial Publisher] |
| spellingShingle | Cognitive functions Early child development Pre-school aged children Schistosomiasis Arthur Vengesai Maritha Kasambala Takafira Mduluza Tariro Mduluza-Jokonya Luxwell Jokonya Herald Midzi Rutendo Birri Makota Arnold Mutemeri Emmanuel Maziti Bazondlile Dube-Marimbe Dixon Chibanda Francisca Mutapi Samson Mukaratirwa Effect of Schistosoma haematobium infection on the cognitive functions of preschool age children and benefits of treatment from an endemic area in Zimbabwe |
| title | Effect of Schistosoma haematobium infection on the cognitive functions of preschool age children and benefits of treatment from an endemic area in Zimbabwe |
| title_full | Effect of Schistosoma haematobium infection on the cognitive functions of preschool age children and benefits of treatment from an endemic area in Zimbabwe |
| title_fullStr | Effect of Schistosoma haematobium infection on the cognitive functions of preschool age children and benefits of treatment from an endemic area in Zimbabwe |
| title_full_unstemmed | Effect of Schistosoma haematobium infection on the cognitive functions of preschool age children and benefits of treatment from an endemic area in Zimbabwe |
| title_short | Effect of Schistosoma haematobium infection on the cognitive functions of preschool age children and benefits of treatment from an endemic area in Zimbabwe |
| title_sort | effect of schistosoma haematobium infection on the cognitive functions of preschool age children and benefits of treatment from an endemic area in zimbabwe |
| topic | Cognitive functions Early child development Pre-school aged children Schistosomiasis |
| url | https://cris.library.msu.ac.zw//handle/11408/5388 |
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