Effects of repeated blood donation on iron status of blood donors in Zimbabwe: a cross-sectional study
Introduction: Iron deficiency is a major complication of repeated blood donation. However, most of the blood screening methods employed by blood collection agents do not include iron status markers, leading to possible subclinical iron deficiency. The aim of this study was to evaluate the effects o...
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Wiley Open Access
2022
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562310/pdf/HSR2-4-e426.pdf http://hdl.handle.net/11408/4654 |
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| author | Vhanda, Donald Chinowaita, Frank Nkomo, Sisodwa Timire, Collins Kouamou, Vinie |
| author_facet | Vhanda, Donald Chinowaita, Frank Nkomo, Sisodwa Timire, Collins Kouamou, Vinie |
| author_sort | Vhanda, Donald |
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| description | Introduction: Iron deficiency is a major complication of repeated blood donation.
However, most of the blood screening methods employed by blood collection agents do not include iron status markers, leading to possible subclinical iron deficiency. The aim of this study was to evaluate the effects of repeated blood donation on the iron status of this vulnerable population in Zimbabwe.
Methods: All donors were categorized into groups based on number of donations
made in the previous 2-year period prior to enrolment into the study. Serum iron,
total iron-binding capacity (TIBC), and ferritin were analyzed on automated chemistry analyzers while transferrin saturation (TSAT) was calculated. The Wilcoxon rank-sum and ANOVA tests were used to assess the variation of iron profiles by gender and frequency of donations. All data analysis was performed using Stata software v13. Results: Study participants included 170 repeat donors and 20 first-time blood donors. The median (IQR) age was 23 (19-27) years, while the majority were males 57% (n = 109/190). The overall prevalence of iron deficiency and reduced iron stores was 12.6% and 38.9%, respectively. There were statistically significant differences between males and females in all the iron status parameters (P < .05). TIBC increased with number of donations, while iron, ferritin, and TSAT decreased with increased number of donations.
Conclusion: A high proportion of blood donors had iron deficiency despite being eligible to donate. Repeated blood donation may lead to substantial reduction in iron stores among blood donors. Inclusion of iron biochemical markers may enhance proper screening and monitoring of blood donors in Zimbabwe to prevent development of iron deficiency anemia. |
| format | Article |
| id | ir-11408-4654 |
| institution | My University |
| language | English |
| publishDate | 2022 |
| publisher | Wiley Open Access |
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| spelling | ir-11408-46542022-06-27T13:49:06Z Effects of repeated blood donation on iron status of blood donors in Zimbabwe: a cross-sectional study Vhanda, Donald Chinowaita, Frank Nkomo, Sisodwa Timire, Collins Kouamou, Vinie blood donation iron deficiency iron status negative iron balance reduced iron stores Introduction: Iron deficiency is a major complication of repeated blood donation. However, most of the blood screening methods employed by blood collection agents do not include iron status markers, leading to possible subclinical iron deficiency. The aim of this study was to evaluate the effects of repeated blood donation on the iron status of this vulnerable population in Zimbabwe. Methods: All donors were categorized into groups based on number of donations made in the previous 2-year period prior to enrolment into the study. Serum iron, total iron-binding capacity (TIBC), and ferritin were analyzed on automated chemistry analyzers while transferrin saturation (TSAT) was calculated. The Wilcoxon rank-sum and ANOVA tests were used to assess the variation of iron profiles by gender and frequency of donations. All data analysis was performed using Stata software v13. Results: Study participants included 170 repeat donors and 20 first-time blood donors. The median (IQR) age was 23 (19-27) years, while the majority were males 57% (n = 109/190). The overall prevalence of iron deficiency and reduced iron stores was 12.6% and 38.9%, respectively. There were statistically significant differences between males and females in all the iron status parameters (P < .05). TIBC increased with number of donations, while iron, ferritin, and TSAT decreased with increased number of donations. Conclusion: A high proportion of blood donors had iron deficiency despite being eligible to donate. Repeated blood donation may lead to substantial reduction in iron stores among blood donors. Inclusion of iron biochemical markers may enhance proper screening and monitoring of blood donors in Zimbabwe to prevent development of iron deficiency anemia. 2022-01-14T09:35:27Z 2022-01-14T09:35:27Z 2021 Article 2398-8835 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562310/pdf/HSR2-4-e426.pdf http://hdl.handle.net/11408/4654 en Health Science Reports;Vol.4, Iss.4 open Wiley Open Access |
| spellingShingle | blood donation iron deficiency iron status negative iron balance reduced iron stores Vhanda, Donald Chinowaita, Frank Nkomo, Sisodwa Timire, Collins Kouamou, Vinie Effects of repeated blood donation on iron status of blood donors in Zimbabwe: a cross-sectional study |
| title | Effects of repeated blood donation on iron status of blood donors in Zimbabwe: a cross-sectional study |
| title_full | Effects of repeated blood donation on iron status of blood donors in Zimbabwe: a cross-sectional study |
| title_fullStr | Effects of repeated blood donation on iron status of blood donors in Zimbabwe: a cross-sectional study |
| title_full_unstemmed | Effects of repeated blood donation on iron status of blood donors in Zimbabwe: a cross-sectional study |
| title_short | Effects of repeated blood donation on iron status of blood donors in Zimbabwe: a cross-sectional study |
| title_sort | effects of repeated blood donation on iron status of blood donors in zimbabwe: a cross-sectional study |
| topic | blood donation iron deficiency iron status negative iron balance reduced iron stores |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562310/pdf/HSR2-4-e426.pdf http://hdl.handle.net/11408/4654 |
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