TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine
In the present study, electrochemical behavior of nevirapine on a glassy carbon electrode (GCE) modified with TiO2 nanoparticles decorated graphene nanoribbons was investigated. Characterization of different components used for modifications was achieved using Fourier transform infrared spectroscopy...
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Hindawi Limited
2021
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| Online Access: | https://www.hindawi.com/journals/jchem/2020/3932715/ http://hdl.handle.net/11408/4276 |
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| author | Apath, Daniel Moyo, Mambo Shumba, Munyaradzi |
| author_facet | Apath, Daniel Moyo, Mambo Shumba, Munyaradzi |
| author_sort | Apath, Daniel |
| collection | DSpace |
| description | In the present study, electrochemical behavior of nevirapine on a glassy carbon electrode (GCE) modified with TiO2 nanoparticles decorated graphene nanoribbons was investigated. Characterization of different components used for modifications was achieved using Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The electrochemical behavior of nevirapine on the modified electrodes was examined using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), chronoamperometry (CA), and differential pulse voltammetry (DPV). A considerable oxidation potential decrease of +352 mV for nevirapine in 0.1 M phosphate-buffered saline (PBS), pH 11.0, was achieved due to synergy offered by graphene nanoribbons and TiO2 compared to graphene nanoribbons (+252 mV) and TiO2 (−37 mV), all with respect to the glassy carbon electrode. Under optimized conditions, DPV gave linear calibrations over the range of 0.020–0.14 µM. The detection limit was calculated as 0.043 µM. The developed sensor was used for determination of nevirapine in a pharmaceutical formulation successfully. |
| format | Article |
| id | ir-11408-4276 |
| institution | My University |
| language | English |
| publishDate | 2021 |
| publisher | Hindawi Limited |
| record_format | dspace |
| spelling | ir-11408-42762022-06-27T13:49:06Z TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine Apath, Daniel Moyo, Mambo Shumba, Munyaradzi TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination Anti-HIV Drug Nevirapine In the present study, electrochemical behavior of nevirapine on a glassy carbon electrode (GCE) modified with TiO2 nanoparticles decorated graphene nanoribbons was investigated. Characterization of different components used for modifications was achieved using Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The electrochemical behavior of nevirapine on the modified electrodes was examined using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), chronoamperometry (CA), and differential pulse voltammetry (DPV). A considerable oxidation potential decrease of +352 mV for nevirapine in 0.1 M phosphate-buffered saline (PBS), pH 11.0, was achieved due to synergy offered by graphene nanoribbons and TiO2 compared to graphene nanoribbons (+252 mV) and TiO2 (−37 mV), all with respect to the glassy carbon electrode. Under optimized conditions, DPV gave linear calibrations over the range of 0.020–0.14 µM. The detection limit was calculated as 0.043 µM. The developed sensor was used for determination of nevirapine in a pharmaceutical formulation successfully. 2021-05-28T11:17:27Z 2021-05-28T11:17:27Z 2020 Article 2090-9071 https://www.hindawi.com/journals/jchem/2020/3932715/ http://hdl.handle.net/11408/4276 en Journal of Chemistry;Vol.2020 ; Article ID 3932715 open Hindawi Limited |
| spellingShingle | TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination Anti-HIV Drug Nevirapine Apath, Daniel Moyo, Mambo Shumba, Munyaradzi TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine |
| title | TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine |
| title_full | TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine |
| title_fullStr | TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine |
| title_full_unstemmed | TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine |
| title_short | TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine |
| title_sort | tio2 nanoparticles decorated graphene nanoribbons for voltammetric determination of an anti-hiv drug nevirapine |
| topic | TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination Anti-HIV Drug Nevirapine |
| url | https://www.hindawi.com/journals/jchem/2020/3932715/ http://hdl.handle.net/11408/4276 |
| work_keys_str_mv | AT apathdaniel tio2nanoparticlesdecoratedgraphenenanoribbonsforvoltammetricdeterminationofanantihivdrugnevirapine AT moyomambo tio2nanoparticlesdecoratedgraphenenanoribbonsforvoltammetricdeterminationofanantihivdrugnevirapine AT shumbamunyaradzi tio2nanoparticlesdecoratedgraphenenanoribbonsforvoltammetricdeterminationofanantihivdrugnevirapine |