The increasing diversity and complexity of the RNA-binding protein repertoire in plants
Post-transcriptional regulation has far-reaching implications on the fate of RNAs. It is gaining increasing momentum as a critical component in adjusting global cellular transcript levels during development and in response to environmental stresses. In this process, RNA-binding proteins (RBPs) are...
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Royal Society Publishing
2021
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| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2020.1397 http://hdl.handle.net/11408/4162 |
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| author | Marondedze, C. |
| author_facet | Marondedze, C. |
| author_sort | Marondedze, C. |
| collection | DSpace |
| description | Post-transcriptional regulation has far-reaching implications on the fate
of RNAs. It is gaining increasing momentum as a critical component in adjusting global cellular transcript levels during development and in response to environmental stresses. In this process, RNA-binding proteins (RBPs) are indispensable chaperones that naturally bind RNA via one or multiple globular RNA-binding domains (RBDs) changing the function or fate of the bound RNAs. Despite the technical challenges faced in plants in large-scale studies, several hundreds of these RBPs have been discovered and elucidated globally over the past few years. Recent discoveries have more than doubled the number of proteins implicated in RNA interaction, including identification of RBPs lacking classical RBDs. This review will discuss these new emerging classes of RBPs, focusing on the current state of the RBP repertoire in Arabidopsis thaliana, including the diverse functional roles derived from quantitative studies implicating RBPs in abiotic stress responses. Notably, this review highlights that 836 RBPs are enriched as Arabidopsis RBPs while 1865 can be classified as candidate RBPs. The review will also outline outstanding areas within this field that require addressing to advance our understanding and potential biotechnological applications of RBPs. |
| format | Article |
| id | ir-11408-4162 |
| institution | My University |
| language | English |
| publishDate | 2021 |
| publisher | Royal Society Publishing |
| record_format | dspace |
| spelling | ir-11408-41622022-06-27T13:49:06Z The increasing diversity and complexity of the RNA-binding protein repertoire in plants Marondedze, C. RNA-binding protein RNA interactome capture UV crosslinking Post-transcriptional regulation has far-reaching implications on the fate of RNAs. It is gaining increasing momentum as a critical component in adjusting global cellular transcript levels during development and in response to environmental stresses. In this process, RNA-binding proteins (RBPs) are indispensable chaperones that naturally bind RNA via one or multiple globular RNA-binding domains (RBDs) changing the function or fate of the bound RNAs. Despite the technical challenges faced in plants in large-scale studies, several hundreds of these RBPs have been discovered and elucidated globally over the past few years. Recent discoveries have more than doubled the number of proteins implicated in RNA interaction, including identification of RBPs lacking classical RBDs. This review will discuss these new emerging classes of RBPs, focusing on the current state of the RBP repertoire in Arabidopsis thaliana, including the diverse functional roles derived from quantitative studies implicating RBPs in abiotic stress responses. Notably, this review highlights that 836 RBPs are enriched as Arabidopsis RBPs while 1865 can be classified as candidate RBPs. The review will also outline outstanding areas within this field that require addressing to advance our understanding and potential biotechnological applications of RBPs. 2021-05-11T12:14:13Z 2021-05-11T12:14:13Z 2020 Article 0962-8452 https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2020.1397 http://hdl.handle.net/11408/4162 en Proceedings of the Royal Society B: Biological Sciences; open Royal Society Publishing |
| spellingShingle | RNA-binding protein RNA interactome capture UV crosslinking Marondedze, C. The increasing diversity and complexity of the RNA-binding protein repertoire in plants |
| title | The increasing diversity and complexity of the RNA-binding protein repertoire in plants |
| title_full | The increasing diversity and complexity of the RNA-binding protein repertoire in plants |
| title_fullStr | The increasing diversity and complexity of the RNA-binding protein repertoire in plants |
| title_full_unstemmed | The increasing diversity and complexity of the RNA-binding protein repertoire in plants |
| title_short | The increasing diversity and complexity of the RNA-binding protein repertoire in plants |
| title_sort | increasing diversity and complexity of the rna-binding protein repertoire in plants |
| topic | RNA-binding protein RNA interactome capture UV crosslinking |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2020.1397 http://hdl.handle.net/11408/4162 |
| work_keys_str_mv | AT marondedzec theincreasingdiversityandcomplexityofthernabindingproteinrepertoireinplants AT marondedzec increasingdiversityandcomplexityofthernabindingproteinrepertoireinplants |