Photophysicochemical and photodynamic therapy properties of metallophthalocyanines linked to gold speckled silica nanoparticles
This work reports on the linkage of 2(3),9(10),16(17),23(24) tetrakis [(benzo[d]thiazol-2-yl phenoxy) phthalocyaninato] zinc(II) (1) and indium(III) chloride (2) to gold speckled silica (GSS) nanoparticles via gold to sulphur (Au-S) and gold to nitrogen (Au-N) self-assembly to form the conjugates: 1...
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Photodiagnosis and Photodynamic Therapy
2020
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| Online Access: | https://www.sciencedirect.com/science/article/abs/pii/S1572100018304186 http://hdl.handle.net/11408/3854 |
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| author | Dube, Edith Oluwole, David, O Nyokong, Tebello Mwaji, Njemuwa Prinsloo, Earl |
| author_facet | Dube, Edith Oluwole, David, O Nyokong, Tebello Mwaji, Njemuwa Prinsloo, Earl |
| author_sort | Dube, Edith |
| collection | DSpace |
| description | This work reports on the linkage of 2(3),9(10),16(17),23(24) tetrakis [(benzo[d]thiazol-2-yl phenoxy) phthalocyaninato] zinc(II) (1) and indium(III) chloride (2) to gold speckled silica (GSS) nanoparticles via gold to sulphur (Au-S) and gold to nitrogen (Au-N) self-assembly to form the conjugates: 1-GSS and 2-GSS. The formed conjugates were characterized using microscopic and spectroscopic techniques, and the photophysicochemical properties and photodynamic therapy (PDT) activity against human breast adenocarcinoma cell line (MCF-7 cells) were studied. The conjugates afforded decrease in fluorescence quantum yields with corresponding increase in triplet and singlet oxygen quantum yields when compared to phthalocyanines alone. Singlet oxygen is cytotoxic to cancer cells hence it is important for PDT. The in vitro dark toxicity of complex 2 and 2-GSS against MCF–7 cells showed ≥93% viable cells within concentration ranges of 10–160 μg/mL. 2–GSS showed enhanced PDT activity with less than 50% viable cells at 80 μg/mL as compared to 2 and GSS alone which showed >60% viable cells within 10–160 μg/mL. The observed improvements in the PDT activity of 2-GSS could be attributed to the high singlet oxygen generation of 2-GSS compared to 2 alone in addition to the phototoxicity of GSS. |
| format | Article |
| id | ir-11408-3854 |
| institution | My University |
| language | English |
| publishDate | 2020 |
| publisher | Photodiagnosis and Photodynamic Therapy |
| record_format | dspace |
| spelling | ir-11408-38542022-06-27T13:49:06Z Photophysicochemical and photodynamic therapy properties of metallophthalocyanines linked to gold speckled silica nanoparticles Dube, Edith Oluwole, David, O Nyokong, Tebello Mwaji, Njemuwa Prinsloo, Earl gold speckled silica phthalocyanine photodynamic therapy This work reports on the linkage of 2(3),9(10),16(17),23(24) tetrakis [(benzo[d]thiazol-2-yl phenoxy) phthalocyaninato] zinc(II) (1) and indium(III) chloride (2) to gold speckled silica (GSS) nanoparticles via gold to sulphur (Au-S) and gold to nitrogen (Au-N) self-assembly to form the conjugates: 1-GSS and 2-GSS. The formed conjugates were characterized using microscopic and spectroscopic techniques, and the photophysicochemical properties and photodynamic therapy (PDT) activity against human breast adenocarcinoma cell line (MCF-7 cells) were studied. The conjugates afforded decrease in fluorescence quantum yields with corresponding increase in triplet and singlet oxygen quantum yields when compared to phthalocyanines alone. Singlet oxygen is cytotoxic to cancer cells hence it is important for PDT. The in vitro dark toxicity of complex 2 and 2-GSS against MCF–7 cells showed ≥93% viable cells within concentration ranges of 10–160 μg/mL. 2–GSS showed enhanced PDT activity with less than 50% viable cells at 80 μg/mL as compared to 2 and GSS alone which showed >60% viable cells within 10–160 μg/mL. The observed improvements in the PDT activity of 2-GSS could be attributed to the high singlet oxygen generation of 2-GSS compared to 2 alone in addition to the phototoxicity of GSS. 2020-10-23T11:33:40Z 2020-10-23T11:33:40Z 2019-03 Article https://www.sciencedirect.com/science/article/abs/pii/S1572100018304186 http://hdl.handle.net/11408/3854 en Vol.25 , 325 - 333; open Photodiagnosis and Photodynamic Therapy |
| spellingShingle | gold speckled silica phthalocyanine photodynamic therapy Dube, Edith Oluwole, David, O Nyokong, Tebello Mwaji, Njemuwa Prinsloo, Earl Photophysicochemical and photodynamic therapy properties of metallophthalocyanines linked to gold speckled silica nanoparticles |
| title | Photophysicochemical and photodynamic therapy properties of metallophthalocyanines linked to gold speckled silica nanoparticles |
| title_full | Photophysicochemical and photodynamic therapy properties of metallophthalocyanines linked to gold speckled silica nanoparticles |
| title_fullStr | Photophysicochemical and photodynamic therapy properties of metallophthalocyanines linked to gold speckled silica nanoparticles |
| title_full_unstemmed | Photophysicochemical and photodynamic therapy properties of metallophthalocyanines linked to gold speckled silica nanoparticles |
| title_short | Photophysicochemical and photodynamic therapy properties of metallophthalocyanines linked to gold speckled silica nanoparticles |
| title_sort | photophysicochemical and photodynamic therapy properties of metallophthalocyanines linked to gold speckled silica nanoparticles |
| topic | gold speckled silica phthalocyanine photodynamic therapy |
| url | https://www.sciencedirect.com/science/article/abs/pii/S1572100018304186 http://hdl.handle.net/11408/3854 |
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