Investigation of photophysicochemical properties of zinc phthalocyanines conjugated to metallic nanoparticles

The syntheses of zinc(II) tetra–[3–(4–phenoxy) (propanoic acid) phthalocyanine] (2) and zinc(II) mono–[3–(4–phenoxy) (propanoic acid) phthalocyanine (3) are reported in this work. Compounds 2 and 3 were covalently linked to glutathione capped silver (AgNPs–GSH), gold (AuNPs–GSH) and silver-gold allo...

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Main Authors: Dube, Edith, Oluwole, David, O, Nyokong, Tebello, Nwaji, Njemuwa, Mack, John
Format: Article
Language:English
Published: Journal of Photochemistry and Photobiology A: Chemistry 2020
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Online Access:https://www.sciencedirect.com/science/article/abs/pii/S1010603017311528
http://hdl.handle.net/11408/3852
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author Dube, Edith
Oluwole, David, O
Nyokong, Tebello
Nwaji, Njemuwa
Mack, John
author_facet Dube, Edith
Oluwole, David, O
Nyokong, Tebello
Nwaji, Njemuwa
Mack, John
author_sort Dube, Edith
collection DSpace
description The syntheses of zinc(II) tetra–[3–(4–phenoxy) (propanoic acid) phthalocyanine] (2) and zinc(II) mono–[3–(4–phenoxy) (propanoic acid) phthalocyanine (3) are reported in this work. Compounds 2 and 3 were covalently linked to glutathione capped silver (AgNPs–GSH), gold (AuNPs–GSH) and silver-gold alloy (Ag3Au1NPs–GSH) nanoparticles (NPs) via an amide bond formation to afford the conjugates: 2–AgNPs–GSH, 3–AgNPs–GSH, 2–AuNPs–GSH, 3–AuNPs–GSH, 2-Ag3Au1NPs–GSH and 3-Ag3Au1NPs–GSH. The photophysicochemical behaviours of the compounds and their conjugates with NPs were assessed in solution. The conjugates afforded a decrease in fluorescence quantum yields and lifetimes with improved triplet quantum yields in comparison to the compounds. Accordingly, the AgNPs and AuNPs conjugates with the compounds afforded high singlet quantum yields. On the contrary, the conjugates of the alloy afforded decreased singlet quantum yields probably due to the screening effect. The compounds and their conjugates with NPs could serve as a viable and efficacious photosensitizer for photodynamic therapy.
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spelling ir-11408-38522022-06-27T13:49:06Z Investigation of photophysicochemical properties of zinc phthalocyanines conjugated to metallic nanoparticles Dube, Edith Oluwole, David, O Nyokong, Tebello Nwaji, Njemuwa Mack, John zinc phthalocyanine Ag-Au nanoparticles triplet quantum yield singlet oxygen quantum yield The syntheses of zinc(II) tetra–[3–(4–phenoxy) (propanoic acid) phthalocyanine] (2) and zinc(II) mono–[3–(4–phenoxy) (propanoic acid) phthalocyanine (3) are reported in this work. Compounds 2 and 3 were covalently linked to glutathione capped silver (AgNPs–GSH), gold (AuNPs–GSH) and silver-gold alloy (Ag3Au1NPs–GSH) nanoparticles (NPs) via an amide bond formation to afford the conjugates: 2–AgNPs–GSH, 3–AgNPs–GSH, 2–AuNPs–GSH, 3–AuNPs–GSH, 2-Ag3Au1NPs–GSH and 3-Ag3Au1NPs–GSH. The photophysicochemical behaviours of the compounds and their conjugates with NPs were assessed in solution. The conjugates afforded a decrease in fluorescence quantum yields and lifetimes with improved triplet quantum yields in comparison to the compounds. Accordingly, the AgNPs and AuNPs conjugates with the compounds afforded high singlet quantum yields. On the contrary, the conjugates of the alloy afforded decreased singlet quantum yields probably due to the screening effect. The compounds and their conjugates with NPs could serve as a viable and efficacious photosensitizer for photodynamic therapy. 2020-10-23T11:31:10Z 2020-10-23T11:31:10Z 2017-12-01 Article https://www.sciencedirect.com/science/article/abs/pii/S1010603017311528 http://hdl.handle.net/11408/3852 en Vol.349 , 148 - 161; open Journal of Photochemistry and Photobiology A: Chemistry
spellingShingle zinc phthalocyanine
Ag-Au nanoparticles
triplet quantum yield
singlet oxygen quantum yield
Dube, Edith
Oluwole, David, O
Nyokong, Tebello
Nwaji, Njemuwa
Mack, John
Investigation of photophysicochemical properties of zinc phthalocyanines conjugated to metallic nanoparticles
title Investigation of photophysicochemical properties of zinc phthalocyanines conjugated to metallic nanoparticles
title_full Investigation of photophysicochemical properties of zinc phthalocyanines conjugated to metallic nanoparticles
title_fullStr Investigation of photophysicochemical properties of zinc phthalocyanines conjugated to metallic nanoparticles
title_full_unstemmed Investigation of photophysicochemical properties of zinc phthalocyanines conjugated to metallic nanoparticles
title_short Investigation of photophysicochemical properties of zinc phthalocyanines conjugated to metallic nanoparticles
title_sort investigation of photophysicochemical properties of zinc phthalocyanines conjugated to metallic nanoparticles
topic zinc phthalocyanine
Ag-Au nanoparticles
triplet quantum yield
singlet oxygen quantum yield
url https://www.sciencedirect.com/science/article/abs/pii/S1010603017311528
http://hdl.handle.net/11408/3852
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AT nyokongtebello investigationofphotophysicochemicalpropertiesofzincphthalocyaninesconjugatedtometallicnanoparticles
AT nwajinjemuwa investigationofphotophysicochemicalpropertiesofzincphthalocyaninesconjugatedtometallicnanoparticles
AT mackjohn investigationofphotophysicochemicalpropertiesofzincphthalocyaninesconjugatedtometallicnanoparticles