Glycosylated zinc phthalocyanine-gold nanoparticle conjugates for photodynamic therapy: Effect of nanoparticle shape
In this work, we report on the synthesis of tris-[(2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methoxy)-2-(4-benzo[d]thiazol-2-ylphenoxyphthalocyaninato] zinc(II) (complex 3) and its linkage to gold nanoparticles (AuNPs) of different shapes through S-Au/N-Au self-ass...
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| Language: | English |
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Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
2020
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| Online Access: | https://www.sciencedirect.com/science/article/abs/pii/S1386142518304815 http://hdl.handle.net/11408/3850 |
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| author | Dube, Edith Oluwole, David, O Nyokong, Tebello Nwaji, Njemuwa |
| author_facet | Dube, Edith Oluwole, David, O Nyokong, Tebello Nwaji, Njemuwa |
| author_sort | Dube, Edith |
| collection | DSpace |
| description | In this work, we report on the synthesis of tris-[(2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methoxy)-2-(4-benzo[d]thiazol-2-ylphenoxyphthalocyaninato] zinc(II) (complex 3) and its linkage to gold nanoparticles (AuNPs) of different shapes through S-Au/N-Au self-assembly. The conjugates of complex 3 (with both gold nanorods (AuNR) and nanospheres (AuNS)), displayed decreased fluorescence quantum yield with corresponding improved triplet and singlet quantum yields compared to complex 3 alone, however 3-AuNR showed improved properties than 3-AuNS. Complex 3 showed relatively low in vitro dark cytotoxicity against the epithelial breast cancer cells with cell survival ≥ 85% at concentration ≤ 160 μg/mL but afforded reduced photodynamic therapy activity which may be due to aggregation. 3-AuNR afforded superior PDT activity with <50% viable cells at concentration ≥ 40 μg/mL in comparison to 3-AuNS with <50% viable cells at concentration ≥ 80 μg/mL. The superior activity of 3-AuNR is attributed to the photothermal therapy effect since nanorods absorb more light at 680 nm than nanospheres. |
| format | Article |
| id | ir-11408-3850 |
| institution | My University |
| language | English |
| publishDate | 2020 |
| publisher | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| record_format | dspace |
| spelling | ir-11408-38502022-06-27T13:49:06Z Glycosylated zinc phthalocyanine-gold nanoparticle conjugates for photodynamic therapy: Effect of nanoparticle shape Dube, Edith Oluwole, David, O Nyokong, Tebello Nwaji, Njemuwa glycosylation zinc phthalocyanine photodynamic therapy gold nanoparticles In this work, we report on the synthesis of tris-[(2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methoxy)-2-(4-benzo[d]thiazol-2-ylphenoxyphthalocyaninato] zinc(II) (complex 3) and its linkage to gold nanoparticles (AuNPs) of different shapes through S-Au/N-Au self-assembly. The conjugates of complex 3 (with both gold nanorods (AuNR) and nanospheres (AuNS)), displayed decreased fluorescence quantum yield with corresponding improved triplet and singlet quantum yields compared to complex 3 alone, however 3-AuNR showed improved properties than 3-AuNS. Complex 3 showed relatively low in vitro dark cytotoxicity against the epithelial breast cancer cells with cell survival ≥ 85% at concentration ≤ 160 μg/mL but afforded reduced photodynamic therapy activity which may be due to aggregation. 3-AuNR afforded superior PDT activity with <50% viable cells at concentration ≥ 40 μg/mL in comparison to 3-AuNS with <50% viable cells at concentration ≥ 80 μg/mL. The superior activity of 3-AuNR is attributed to the photothermal therapy effect since nanorods absorb more light at 680 nm than nanospheres. 2020-10-23T11:30:18Z 2020-10-23T11:30:18Z 2018-10-05 Article https://www.sciencedirect.com/science/article/abs/pii/S1386142518304815 http://hdl.handle.net/11408/3850 en Vol.203 , 85 - 95; open Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| spellingShingle | glycosylation zinc phthalocyanine photodynamic therapy gold nanoparticles Dube, Edith Oluwole, David, O Nyokong, Tebello Nwaji, Njemuwa Glycosylated zinc phthalocyanine-gold nanoparticle conjugates for photodynamic therapy: Effect of nanoparticle shape |
| title | Glycosylated zinc phthalocyanine-gold nanoparticle conjugates for photodynamic therapy: Effect of nanoparticle shape |
| title_full | Glycosylated zinc phthalocyanine-gold nanoparticle conjugates for photodynamic therapy: Effect of nanoparticle shape |
| title_fullStr | Glycosylated zinc phthalocyanine-gold nanoparticle conjugates for photodynamic therapy: Effect of nanoparticle shape |
| title_full_unstemmed | Glycosylated zinc phthalocyanine-gold nanoparticle conjugates for photodynamic therapy: Effect of nanoparticle shape |
| title_short | Glycosylated zinc phthalocyanine-gold nanoparticle conjugates for photodynamic therapy: Effect of nanoparticle shape |
| title_sort | glycosylated zinc phthalocyanine-gold nanoparticle conjugates for photodynamic therapy: effect of nanoparticle shape |
| topic | glycosylation zinc phthalocyanine photodynamic therapy gold nanoparticles |
| url | https://www.sciencedirect.com/science/article/abs/pii/S1386142518304815 http://hdl.handle.net/11408/3850 |
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