The Relationship between Pain and Vascular Function Biomarkers in Dysmenorrheal University Students
Our aim was to establish if the secretion of contactin 1 (CNTN-1), a widely researched pain biomarker correlates with the severity of dysmenorrhea and circulating levels of vascular cell adhesion molecule 1 (VCAM-1) and angiotensin II (ANG-II). This study was a longitudinal randomized clinical study...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Chonnam National University Medical School and the Chonnam University Research Institute of Medical Sciences
2022
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/11408/5172 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1779905268555972608 |
|---|---|
| author | Njoku, Uche Chinedu Amadi, Peter Uchenna Agomuo, Emmanuel Nnabugwu Bhebhe, Michael |
| author_facet | Njoku, Uche Chinedu Amadi, Peter Uchenna Agomuo, Emmanuel Nnabugwu Bhebhe, Michael |
| author_sort | Njoku, Uche Chinedu |
| collection | DSpace |
| description | Our aim was to establish if the secretion of contactin 1 (CNTN-1), a widely researched pain biomarker correlates with the severity of dysmenorrhea and circulating levels of vascular cell adhesion molecule 1 (VCAM-1) and angiotensin II (ANG-II). This study was a longitudinal randomized clinical study that involved 95 female students between 17-25 years. The control participant group were students who, without medications, had not experienced dysmenorrhea, while the inclusion criteria were primary dysmenorrhea without medications. Data was collected using demographic questionnaires that also contained the Numeric Rating Scale (NRS-11), while blood samples were collected for analysis of CNTN-1, VCAM-1 and ANG-II by ELISA. The participants' mean BMI's across the four pain strata were between 16.60-38.43 kg/m2 and in addition to age and menarche, showed no correlation to either the NRS-11 scale (r=-0.01214) or their CNTN-1 levels (r=0.009622). The severe dysmenorrhea group showed statistically higher (p<0.0001) and positive correlation to systolic (r=0.7304) and diastolic (0.6588) blood pressures. The contactin 1 levels (7.00-55.70 ng/mL) increased with higher menstrual pain and as the pain increased, so did the mean VCAM-1 and ANG-II levels (p<0.0001). A positive linear correlation (r=0.9691) was observed between the NRS-11 scale of the participants and their CNTN-1 activities while the CNTN-1 levels positively correlated with their VCAM-1 (r=0.9334) and ANG-II (r=0.8746) secretion. In summary, the severity of dysmenorrheal pain elevates the contactin 1 levels which affects their vascular health and blood pressure. |
| format | Article |
| id | ir-11408-5172 |
| institution | My University |
| language | English |
| publishDate | 2022 |
| publisher | Chonnam National University Medical School and the Chonnam University Research Institute of Medical Sciences |
| record_format | dspace |
| spelling | ir-11408-51722022-09-30T06:35:43Z The Relationship between Pain and Vascular Function Biomarkers in Dysmenorrheal University Students Njoku, Uche Chinedu Amadi, Peter Uchenna Agomuo, Emmanuel Nnabugwu Bhebhe, Michael Angiotensin II Blood Pressure Contactin 1 Dysmenorrhea Our aim was to establish if the secretion of contactin 1 (CNTN-1), a widely researched pain biomarker correlates with the severity of dysmenorrhea and circulating levels of vascular cell adhesion molecule 1 (VCAM-1) and angiotensin II (ANG-II). This study was a longitudinal randomized clinical study that involved 95 female students between 17-25 years. The control participant group were students who, without medications, had not experienced dysmenorrhea, while the inclusion criteria were primary dysmenorrhea without medications. Data was collected using demographic questionnaires that also contained the Numeric Rating Scale (NRS-11), while blood samples were collected for analysis of CNTN-1, VCAM-1 and ANG-II by ELISA. The participants' mean BMI's across the four pain strata were between 16.60-38.43 kg/m2 and in addition to age and menarche, showed no correlation to either the NRS-11 scale (r=-0.01214) or their CNTN-1 levels (r=0.009622). The severe dysmenorrhea group showed statistically higher (p<0.0001) and positive correlation to systolic (r=0.7304) and diastolic (0.6588) blood pressures. The contactin 1 levels (7.00-55.70 ng/mL) increased with higher menstrual pain and as the pain increased, so did the mean VCAM-1 and ANG-II levels (p<0.0001). A positive linear correlation (r=0.9691) was observed between the NRS-11 scale of the participants and their CNTN-1 activities while the CNTN-1 levels positively correlated with their VCAM-1 (r=0.9334) and ANG-II (r=0.8746) secretion. In summary, the severity of dysmenorrheal pain elevates the contactin 1 levels which affects their vascular health and blood pressure. 2022-09-30T06:35:43Z 2022-09-30T06:35:43Z 2020-09-24 Article Njoku UC, Amadi PU, Agomuo EN, Bhebhe M. The Relationship between Pain and Vascular Function Biomarkers in Dysmenorrheal University Students. Chonnam Med J. 2020 Sep;56(3):186-190. doi: 10.4068/cmj.2020.56.3.186. Epub 2020 Sep 24. PMID: 33014757; PMCID: PMC7520371. 2233-7385 2233-7393 10.4068/cmj.2020.56.3.186 http://hdl.handle.net/11408/5172 en Chonnam Medical Journal;Vol. 56, No. 3, Pages 186-190 open Chonnam National University Medical School and the Chonnam University Research Institute of Medical Sciences |
| spellingShingle | Angiotensin II Blood Pressure Contactin 1 Dysmenorrhea Njoku, Uche Chinedu Amadi, Peter Uchenna Agomuo, Emmanuel Nnabugwu Bhebhe, Michael The Relationship between Pain and Vascular Function Biomarkers in Dysmenorrheal University Students |
| title | The Relationship between Pain and Vascular Function Biomarkers in Dysmenorrheal University Students |
| title_full | The Relationship between Pain and Vascular Function Biomarkers in Dysmenorrheal University Students |
| title_fullStr | The Relationship between Pain and Vascular Function Biomarkers in Dysmenorrheal University Students |
| title_full_unstemmed | The Relationship between Pain and Vascular Function Biomarkers in Dysmenorrheal University Students |
| title_short | The Relationship between Pain and Vascular Function Biomarkers in Dysmenorrheal University Students |
| title_sort | relationship between pain and vascular function biomarkers in dysmenorrheal university students |
| topic | Angiotensin II Blood Pressure Contactin 1 Dysmenorrhea |
| url | http://hdl.handle.net/11408/5172 |
| work_keys_str_mv | AT njokuuchechinedu therelationshipbetweenpainandvascularfunctionbiomarkersindysmenorrhealuniversitystudents AT amadipeteruchenna therelationshipbetweenpainandvascularfunctionbiomarkersindysmenorrhealuniversitystudents AT agomuoemmanuelnnabugwu therelationshipbetweenpainandvascularfunctionbiomarkersindysmenorrhealuniversitystudents AT bhebhemichael therelationshipbetweenpainandvascularfunctionbiomarkersindysmenorrhealuniversitystudents AT njokuuchechinedu relationshipbetweenpainandvascularfunctionbiomarkersindysmenorrhealuniversitystudents AT amadipeteruchenna relationshipbetweenpainandvascularfunctionbiomarkersindysmenorrhealuniversitystudents AT agomuoemmanuelnnabugwu relationshipbetweenpainandvascularfunctionbiomarkersindysmenorrhealuniversitystudents AT bhebhemichael relationshipbetweenpainandvascularfunctionbiomarkersindysmenorrhealuniversitystudents |