Deorphaning anti-tuberculosis compounds using chemogenomic approaches and data from the ChEMBL database
The emergence of drug resistant strains of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), calls for an urgent need for new drugs that have distinct mechanisms of action. To date, several thousands of active compounds against tuberculosis have been identified through high...
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| Format: | Presentation |
| Language: | English |
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Elsevier
2022
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| Online Access: | http://hdl.handle.net/11408/4931 |
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| author | Mugumbate, G. Papadatos, G. Overington, J.P. |
| author_facet | Mugumbate, G. Papadatos, G. Overington, J.P. |
| author_sort | Mugumbate, G. |
| collection | DSpace |
| description | The emergence of drug resistant strains of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), calls for an urgent need for new drugs that have distinct mechanisms of action. To date, several thousands of active compounds against tuberculosis have been identified through high throughput screening (HTS). The challenge then rests identifying the molecular targets and characterising the mechanism of action of these actives. |
| format | Presentation |
| id | ir-11408-4931 |
| institution | My University |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | ir-11408-49312022-06-28T12:42:39Z Deorphaning anti-tuberculosis compounds using chemogenomic approaches and data from the ChEMBL database Mugumbate, G. Papadatos, G. Overington, J.P. Mycobacterium tuberculosis (Mtb) high throughput screening (HTS) tuberculosis (TB) The emergence of drug resistant strains of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), calls for an urgent need for new drugs that have distinct mechanisms of action. To date, several thousands of active compounds against tuberculosis have been identified through high throughput screening (HTS). The challenge then rests identifying the molecular targets and characterising the mechanism of action of these actives. 2022-06-28T12:42:39Z 2022-06-28T12:42:39Z 2014 Presentation 1201-9712 DOI:https://doi.org/10.1016/j.ijid.2014.03.834 http://hdl.handle.net/11408/4931 en International Journal of Infectious Diseases (IJID);Volume 21, Supplement 1, 198. open Elsevier |
| spellingShingle | Mycobacterium tuberculosis (Mtb) high throughput screening (HTS) tuberculosis (TB) Mugumbate, G. Papadatos, G. Overington, J.P. Deorphaning anti-tuberculosis compounds using chemogenomic approaches and data from the ChEMBL database |
| title | Deorphaning anti-tuberculosis compounds using chemogenomic approaches and data from the ChEMBL database |
| title_full | Deorphaning anti-tuberculosis compounds using chemogenomic approaches and data from the ChEMBL database |
| title_fullStr | Deorphaning anti-tuberculosis compounds using chemogenomic approaches and data from the ChEMBL database |
| title_full_unstemmed | Deorphaning anti-tuberculosis compounds using chemogenomic approaches and data from the ChEMBL database |
| title_short | Deorphaning anti-tuberculosis compounds using chemogenomic approaches and data from the ChEMBL database |
| title_sort | deorphaning anti-tuberculosis compounds using chemogenomic approaches and data from the chembl database |
| topic | Mycobacterium tuberculosis (Mtb) high throughput screening (HTS) tuberculosis (TB) |
| url | http://hdl.handle.net/11408/4931 |
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