Synthesis and in Vitro and in Vivo Pharmacological Evaluation of New 4-Aminoquinoline-Based Compounds

A new class of 4-aminoquinolines was synthesized and evaluated in vitro for antiplasmodial activity against both the chloroquine-sensitive (3D7) and -resistant (K1 and W2) strains. The most active compounds 3c–3e had acceptable cytotoxicity but showed strong inhibition toward a panel of cytochrome P...

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Bibliographic Details
Main Authors:	Tukulula, Matshawandile, Njoroge, Mathew, Abay, Efrem T., Mugumbate, Grace C., Wiesner, Lubbe, Taylor, Dale, Gibhard, Liezl, Norman, Jennifer, Swart, Kenneth J., Gut, Jiri, Rosenthal, Philip J., Barteau, Samuel, Streckfuss, Judith, Kameni-Tcheudji, Jacques, Chibale, Kelly
Format:	Article
Language:	English
Published:	American Chemical Society 2022
Subjects:	Aminoquinolines antiplasmodial activity pharmacokinetics Plasma protein binding
Online Access:	https://doi.org/10.1021/ml400311r http://hdl.handle.net/11408/4922
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Synthesis and in Vitro and in Vivo Pharmacological Evaluation of New 4-Aminoquinoline-Based Compounds