Natural Products: A Potential Source of Malaria Transmission Blocking Drugs?
The ability to block human-to-mosquito and mosquito-to-human transmission ofPlasmodiumparasites is fundamental to accomplish the ambitious goal of malaria elimination. The WHO currentlyrecommends only primaquine as a transmission-blocking drug but its use is severely restrictedby toxicity in some po...
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| Format: | Article |
| Language: | English |
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Multidisciplinary Digital Publishing Institute
2022
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| Online Access: | http://hdl.handle.net/11408/4877 |
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| author | Mugumbate, Grace Moyo, Phanankosi Elof, Jacobus N. Louw, Abraham I. Maharaj, Vinesh J. Birkholtz, Lyn-Marié |
| author_facet | Mugumbate, Grace Moyo, Phanankosi Elof, Jacobus N. Louw, Abraham I. Maharaj, Vinesh J. Birkholtz, Lyn-Marié |
| author_sort | Mugumbate, Grace |
| collection | DSpace |
| description | The ability to block human-to-mosquito and mosquito-to-human transmission ofPlasmodiumparasites is fundamental to accomplish the ambitious goal of malaria elimination. The WHO currentlyrecommends only primaquine as a transmission-blocking drug but its use is severely restrictedby toxicity in some populations. New, safe and clinically effective transmission-blocking drugstherefore need to be discovered. While natural products have been extensively investigated for thedevelopment of chemotherapeutic antimalarial agents, their potential use as transmission-blockingdrugs is comparatively poorly explored. Here, we provide a comprehensive summary of the activitiesof natural products (and their derivatives) of plant and microbial origins against sexual stages ofPlasmodiumparasites and theAnophelesmosquito vector. We identify the prevailing challenges andopportunities and suggest how these can be mitigated and/or exploited in an endeavor to expeditetransmission-blocking drug discovery efforts from natural products. |
| format | Article |
| id | ir-11408-4877 |
| institution | My University |
| language | English |
| publishDate | 2022 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | ir-11408-48772022-06-27T13:49:06Z Natural Products: A Potential Source of Malaria Transmission Blocking Drugs? Mugumbate, Grace Moyo, Phanankosi Elof, Jacobus N. Louw, Abraham I. Maharaj, Vinesh J. Birkholtz, Lyn-Marié transmission blocking Plasmodium Anopheles natural products The ability to block human-to-mosquito and mosquito-to-human transmission ofPlasmodiumparasites is fundamental to accomplish the ambitious goal of malaria elimination. The WHO currentlyrecommends only primaquine as a transmission-blocking drug but its use is severely restrictedby toxicity in some populations. New, safe and clinically effective transmission-blocking drugstherefore need to be discovered. While natural products have been extensively investigated for thedevelopment of chemotherapeutic antimalarial agents, their potential use as transmission-blockingdrugs is comparatively poorly explored. Here, we provide a comprehensive summary of the activitiesof natural products (and their derivatives) of plant and microbial origins against sexual stages ofPlasmodiumparasites and theAnophelesmosquito vector. We identify the prevailing challenges andopportunities and suggest how these can be mitigated and/or exploited in an endeavor to expeditetransmission-blocking drug discovery efforts from natural products. 2022-05-27T09:59:35Z 2022-05-27T09:59:35Z 2020-08 Article 1424-8247 http://hdl.handle.net/11408/4877 en Pharmaceuticals;13 open Multidisciplinary Digital Publishing Institute |
| spellingShingle | transmission blocking Plasmodium Anopheles natural products Mugumbate, Grace Moyo, Phanankosi Elof, Jacobus N. Louw, Abraham I. Maharaj, Vinesh J. Birkholtz, Lyn-Marié Natural Products: A Potential Source of Malaria Transmission Blocking Drugs? |
| title | Natural Products: A Potential Source of Malaria Transmission Blocking Drugs? |
| title_full | Natural Products: A Potential Source of Malaria Transmission Blocking Drugs? |
| title_fullStr | Natural Products: A Potential Source of Malaria Transmission Blocking Drugs? |
| title_full_unstemmed | Natural Products: A Potential Source of Malaria Transmission Blocking Drugs? |
| title_short | Natural Products: A Potential Source of Malaria Transmission Blocking Drugs? |
| title_sort | natural products: a potential source of malaria transmission blocking drugs? |
| topic | transmission blocking Plasmodium Anopheles natural products |
| url | http://hdl.handle.net/11408/4877 |
| work_keys_str_mv | AT mugumbategrace naturalproductsapotentialsourceofmalariatransmissionblockingdrugs AT moyophanankosi naturalproductsapotentialsourceofmalariatransmissionblockingdrugs AT elofjacobusn naturalproductsapotentialsourceofmalariatransmissionblockingdrugs AT louwabrahami naturalproductsapotentialsourceofmalariatransmissionblockingdrugs AT maharajvineshj naturalproductsapotentialsourceofmalariatransmissionblockingdrugs AT birkholtzlynmarie naturalproductsapotentialsourceofmalariatransmissionblockingdrugs |