Co-crystals and salts of vanillic acid and vanillin with amines
Vanillin (VAN) and its oxidized form vanillic acid (VA) have successfully formed a series of co-crystals and salts. VAN formed a co-crystal with isonicotinamide (INM) and a co-crystal hydrate with theobromine (THB). Binary co-crystals of VA with isonicotinamide (INM), hexamethylenetetramine (HEXA),...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2021
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| Subjects: | |
| Online Access: | https://pubs.rsc.org/en/content/articlelanding/2018/ce/c7ce02022h http://hdl.handle.net/11408/4557 |
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| Summary: | Vanillin (VAN) and its oxidized form vanillic acid (VA) have successfully formed a series of co-crystals and salts. VAN formed a co-crystal with isonicotinamide (INM) and a co-crystal hydrate with theobromine (THB). Binary co-crystals of VA with isonicotinamide (INM), hexamethylenetetramine (HEXA), phenazine (PHZ) and pyrazine-N-oxide (PZO) were obtained. Interestingly, a ternary co-crystal resulted from a 1 : 1 : 1 ratio of VA, caffeine (CAF) and nicotinamide (NAM). Salt hydrates were also formed between piperazine (PPZ) and 1,4-diazabicyclo[2.2.2]octane (DABCO) with VA. All co-crystals and salts were characterized by X-ray diffraction techniques, thermal analysis and infrared spectroscopy. |
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