One-Pot Synthesized Nickel-Cobalt Sulfide-Decorated Graphene Quantum Dot Composite for Simultaneous Electrochemical Determination of Antiretroviral Drugs: Lamivudine and Tenofovir Disoproxil Fumarate
In the present study, simultaneous electrochemical behavior of tenofovir disoproxil fumarate (TDF) and lamivudine (LAM) on a glassy carbon electrode (GCE) modified with a novel nanocomposite, nickel-cobalt sulfide-decorated graphene quantum dots (Ni-CoS/GQDs) was investigated. Characterization of di...
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Hindawi Limited
2021
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| Online Access: | https://www.hindawi.com/journals/js/2020/3124102/ http://hdl.handle.net/11408/4274 |
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| author | Chihava, Ruvimbo Apath, Daniel Moyo, Mambo Shumba, Munyaradzi Chitsa, Vitalis Tshuma, Piwai |
| author_facet | Chihava, Ruvimbo Apath, Daniel Moyo, Mambo Shumba, Munyaradzi Chitsa, Vitalis Tshuma, Piwai |
| author_sort | Chihava, Ruvimbo |
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| description | In the present study, simultaneous electrochemical behavior of tenofovir disoproxil fumarate (TDF) and lamivudine (LAM) on a glassy carbon electrode (GCE) modified with a novel nanocomposite, nickel-cobalt sulfide-decorated graphene quantum dots (Ni-CoS/GQDs) was investigated. Characterization of different components used for modifications was achieved using UV-Vis and transmission electron microscopy (TEM). The electrochemistry of TDF and LAM at the modified electrode was examined using cyclic voltammetry (CV), linear sweep voltammetry (LSV), chronoamperometry, differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). A substantial (+39 mV TDF; +20 mV LAM) decrease in potential on oxidation reaction in 0.1 M PBS (pH 8.0) was achieved due to synergy between Ni-CoS and GQDs. Using optimized voltammetric parameters and pH, DPV gave a linear calibration over the range 5-18 μM for TDF and LAM. The detection limits were calculated as mM (LAM) and mM (TDF). The estimated values for Gibbs free energy revealed adsorption of TDF and LAM on Ni-CoS/GQDs/GCE as a spontaneous and favorable process. The voltammetric method was applied for determination of LAM and TDF in a pharmaceutical formulation giving average recovery of 99.65%. |
| format | Article |
| id | ir-11408-4274 |
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| language | English |
| publishDate | 2021 |
| publisher | Hindawi Limited |
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| spelling | ir-11408-42742022-06-27T13:49:06Z One-Pot Synthesized Nickel-Cobalt Sulfide-Decorated Graphene Quantum Dot Composite for Simultaneous Electrochemical Determination of Antiretroviral Drugs: Lamivudine and Tenofovir Disoproxil Fumarate Chihava, Ruvimbo Apath, Daniel Moyo, Mambo Shumba, Munyaradzi Chitsa, Vitalis Tshuma, Piwai One-Pot Synthesized Nicke Cobalt Sulfide Decorated Graphene Quantum Dot Composite Simultaneous Electrochemical Determination Antiretroviral Drugs Lamivudine Tenofovir Disoproxil Fumarate In the present study, simultaneous electrochemical behavior of tenofovir disoproxil fumarate (TDF) and lamivudine (LAM) on a glassy carbon electrode (GCE) modified with a novel nanocomposite, nickel-cobalt sulfide-decorated graphene quantum dots (Ni-CoS/GQDs) was investigated. Characterization of different components used for modifications was achieved using UV-Vis and transmission electron microscopy (TEM). The electrochemistry of TDF and LAM at the modified electrode was examined using cyclic voltammetry (CV), linear sweep voltammetry (LSV), chronoamperometry, differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). A substantial (+39 mV TDF; +20 mV LAM) decrease in potential on oxidation reaction in 0.1 M PBS (pH 8.0) was achieved due to synergy between Ni-CoS and GQDs. Using optimized voltammetric parameters and pH, DPV gave a linear calibration over the range 5-18 μM for TDF and LAM. The detection limits were calculated as mM (LAM) and mM (TDF). The estimated values for Gibbs free energy revealed adsorption of TDF and LAM on Ni-CoS/GQDs/GCE as a spontaneous and favorable process. The voltammetric method was applied for determination of LAM and TDF in a pharmaceutical formulation giving average recovery of 99.65%. 2021-05-28T11:11:15Z 2021-05-28T11:11:15Z 2020 Article 1687-7268 https://www.hindawi.com/journals/js/2020/3124102/ http://hdl.handle.net/11408/4274 en Journal of Sensors;Vol.20 ; Article ID 3124102 open Hindawi Limited |
| spellingShingle | One-Pot Synthesized Nicke Cobalt Sulfide Decorated Graphene Quantum Dot Composite Simultaneous Electrochemical Determination Antiretroviral Drugs Lamivudine Tenofovir Disoproxil Fumarate Chihava, Ruvimbo Apath, Daniel Moyo, Mambo Shumba, Munyaradzi Chitsa, Vitalis Tshuma, Piwai One-Pot Synthesized Nickel-Cobalt Sulfide-Decorated Graphene Quantum Dot Composite for Simultaneous Electrochemical Determination of Antiretroviral Drugs: Lamivudine and Tenofovir Disoproxil Fumarate |
| title | One-Pot Synthesized Nickel-Cobalt Sulfide-Decorated Graphene Quantum Dot Composite for Simultaneous Electrochemical Determination of Antiretroviral Drugs: Lamivudine and Tenofovir Disoproxil Fumarate |
| title_full | One-Pot Synthesized Nickel-Cobalt Sulfide-Decorated Graphene Quantum Dot Composite for Simultaneous Electrochemical Determination of Antiretroviral Drugs: Lamivudine and Tenofovir Disoproxil Fumarate |
| title_fullStr | One-Pot Synthesized Nickel-Cobalt Sulfide-Decorated Graphene Quantum Dot Composite for Simultaneous Electrochemical Determination of Antiretroviral Drugs: Lamivudine and Tenofovir Disoproxil Fumarate |
| title_full_unstemmed | One-Pot Synthesized Nickel-Cobalt Sulfide-Decorated Graphene Quantum Dot Composite for Simultaneous Electrochemical Determination of Antiretroviral Drugs: Lamivudine and Tenofovir Disoproxil Fumarate |
| title_short | One-Pot Synthesized Nickel-Cobalt Sulfide-Decorated Graphene Quantum Dot Composite for Simultaneous Electrochemical Determination of Antiretroviral Drugs: Lamivudine and Tenofovir Disoproxil Fumarate |
| title_sort | one-pot synthesized nickel-cobalt sulfide-decorated graphene quantum dot composite for simultaneous electrochemical determination of antiretroviral drugs: lamivudine and tenofovir disoproxil fumarate |
| topic | One-Pot Synthesized Nicke Cobalt Sulfide Decorated Graphene Quantum Dot Composite Simultaneous Electrochemical Determination Antiretroviral Drugs Lamivudine Tenofovir Disoproxil Fumarate |
| url | https://www.hindawi.com/journals/js/2020/3124102/ http://hdl.handle.net/11408/4274 |
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