Growth trajectories of HIV exposed and HIV unexposed infants: a prospective study in Gweru, Zimbabwe
Background: With the increasing HIV seroprevalence among women of childbearing age in sub-Saharan Africa, limited data on growth outcomes of HIV exposed infants under current policies of universal maternal antiretroviral therapy exist. Methods: The longitudinal growth patterns of 114 HIV expose...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2021
|
| Subjects: | |
| Online Access: | https://journals.sagepub.com/doi/full/10.1177/2333794X21990338 http://hdl.handle.net/11408/4122 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1779905251478863872 |
|---|---|
| author | Mabaya, Lucy Matarira, Hilda Tendisa Tanyanyiwa, Donald Moshen Musarurwa, Cuthbert Mukwembi, Johannes |
| author_facet | Mabaya, Lucy Matarira, Hilda Tendisa Tanyanyiwa, Donald Moshen Musarurwa, Cuthbert Mukwembi, Johannes |
| author_sort | Mabaya, Lucy |
| collection | DSpace |
| description | Background:
With the increasing HIV seroprevalence among women of childbearing age in sub-Saharan Africa, limited data on growth outcomes of HIV exposed infants under current policies of universal maternal antiretroviral therapy exist.
Methods:
The longitudinal growth patterns of 114 HIV exposed and unexposed infants were assessed and compared. The prevalence and factors associated with malnutrition were established. Infants under prevention of mother to child transmission care were recruited at 6 weeks post-delivery as were their HIV unexposed counterparts. Weight and length measurements were recorded at birth, 6 and 16 weeks postpartum.
Results:
HIV vertical transmission rate was 8.8%. HIV exposed infants had significantly lower mean birth weights compared to HIV unexposed infants (2.9 ± 0.3; 3.2 ± 0.5; P < .001) respectively. Mean weight/length-for-age z-scores for HIV exposed, uninfected (HEU) infants were significantly below those of the HIV unexposed infants during follow up. By 6 weeks of age, 28.5% of HEU infants were malnourished while no malnutrition was evident in HIV unexposed infants. A gestational age <37 weeks (OR: 3.83; 95% CI: 1.03-14.30; P = .045) and HIV exposure (OR: 1.62; 95% CI: 0.17-15.73; P = .017) substantially increased the risk of stunting.
Conclusion:
Growth deficits were witnessed in HIV exposed infants compared to HIV unexposed infants. There is need for early nutritional monitoring and support among HIV exposed infants. |
| format | Article |
| id | ir-11408-4122 |
| institution | My University |
| language | English |
| publishDate | 2021 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | ir-11408-41222022-06-27T13:49:06Z Growth trajectories of HIV exposed and HIV unexposed infants: a prospective study in Gweru, Zimbabwe Mabaya, Lucy Matarira, Hilda Tendisa Tanyanyiwa, Donald Moshen Musarurwa, Cuthbert Mukwembi, Johannes Antiretroviral therapy HIV Infants Growth Background: With the increasing HIV seroprevalence among women of childbearing age in sub-Saharan Africa, limited data on growth outcomes of HIV exposed infants under current policies of universal maternal antiretroviral therapy exist. Methods: The longitudinal growth patterns of 114 HIV exposed and unexposed infants were assessed and compared. The prevalence and factors associated with malnutrition were established. Infants under prevention of mother to child transmission care were recruited at 6 weeks post-delivery as were their HIV unexposed counterparts. Weight and length measurements were recorded at birth, 6 and 16 weeks postpartum. Results: HIV vertical transmission rate was 8.8%. HIV exposed infants had significantly lower mean birth weights compared to HIV unexposed infants (2.9 ± 0.3; 3.2 ± 0.5; P < .001) respectively. Mean weight/length-for-age z-scores for HIV exposed, uninfected (HEU) infants were significantly below those of the HIV unexposed infants during follow up. By 6 weeks of age, 28.5% of HEU infants were malnourished while no malnutrition was evident in HIV unexposed infants. A gestational age <37 weeks (OR: 3.83; 95% CI: 1.03-14.30; P = .045) and HIV exposure (OR: 1.62; 95% CI: 0.17-15.73; P = .017) substantially increased the risk of stunting. Conclusion: Growth deficits were witnessed in HIV exposed infants compared to HIV unexposed infants. There is need for early nutritional monitoring and support among HIV exposed infants. 2021-05-06T12:17:15Z 2021-05-06T12:17:15Z 2021 Article 2333-794X https://journals.sagepub.com/doi/full/10.1177/2333794X21990338 http://hdl.handle.net/11408/4122 en Global Pediatric Health Volume 8: 1–10; open SAGE Publications |
| spellingShingle | Antiretroviral therapy HIV Infants Growth Mabaya, Lucy Matarira, Hilda Tendisa Tanyanyiwa, Donald Moshen Musarurwa, Cuthbert Mukwembi, Johannes Growth trajectories of HIV exposed and HIV unexposed infants: a prospective study in Gweru, Zimbabwe |
| title | Growth trajectories of HIV exposed and HIV unexposed infants: a prospective study in Gweru, Zimbabwe |
| title_full | Growth trajectories of HIV exposed and HIV unexposed infants: a prospective study in Gweru, Zimbabwe |
| title_fullStr | Growth trajectories of HIV exposed and HIV unexposed infants: a prospective study in Gweru, Zimbabwe |
| title_full_unstemmed | Growth trajectories of HIV exposed and HIV unexposed infants: a prospective study in Gweru, Zimbabwe |
| title_short | Growth trajectories of HIV exposed and HIV unexposed infants: a prospective study in Gweru, Zimbabwe |
| title_sort | growth trajectories of hiv exposed and hiv unexposed infants: a prospective study in gweru, zimbabwe |
| topic | Antiretroviral therapy HIV Infants Growth |
| url | https://journals.sagepub.com/doi/full/10.1177/2333794X21990338 http://hdl.handle.net/11408/4122 |
| work_keys_str_mv | AT mabayalucy growthtrajectoriesofhivexposedandhivunexposedinfantsaprospectivestudyingweruzimbabwe AT matarirahildatendisa growthtrajectoriesofhivexposedandhivunexposedinfantsaprospectivestudyingweruzimbabwe AT tanyanyiwadonaldmoshen growthtrajectoriesofhivexposedandhivunexposedinfantsaprospectivestudyingweruzimbabwe AT musarurwacuthbert growthtrajectoriesofhivexposedandhivunexposedinfantsaprospectivestudyingweruzimbabwe AT mukwembijohannes growthtrajectoriesofhivexposedandhivunexposedinfantsaprospectivestudyingweruzimbabwe |