Cardiovascular effects of Boophone disticha aqueous ethanolic extract on early maternally separated BALB/C mice
Ethnopharmacological relevance: There are a number of reports from traditional medical practice in Zimbabwe and neighboring countries and few in vitro studies suggesting an effect with extracts of Boophone disticha in some forms of anxiety disorder. Aim of the study: In order to validate the use of...
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/11408/1675 http://www.sciencedirect.com/science/article/pii/S0378874113001426 |
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| author | Pote, William Tagwireyi, Dexter Chinyanga, Herbert M. Musara, Collin Nyandoro, George Chifamba, Jephat Nkomozepi, Pilani |
| author_facet | Pote, William Tagwireyi, Dexter Chinyanga, Herbert M. Musara, Collin Nyandoro, George Chifamba, Jephat Nkomozepi, Pilani |
| author_sort | Pote, William |
| collection | DSpace |
| description | Ethnopharmacological relevance: There are a number of reports from traditional medical practice in Zimbabwe and neighboring countries and few in vitro studies suggesting an effect with extracts of Boophone disticha in some forms of anxiety disorder.
Aim of the study: In order to validate the use of Boophone disticha in treatment of anxiety, this study was set to determine the effects of the plant extracts on blood pressure (BP) and heart rate (HR) in adult BALB/c mice subjected to repeated early maternal separation (MS) stress.
Materials and methods: To test whether early life stress increases anxiety in mice, non-invasive tail cuff method was used to examine the autonomic nervous system activity by assessing cardiovascular reactivity and response to acute mixing stress (AMS) and restraint stress (RS) in adult mice subjected to early postnatal stress as compared to control. AMS-induced cardiovascular response was then evaluated in adult MS mice treated with Boophone disticha as compared to vehicle and diazepam.
Results: Comparisons of the BP and HR measurements indicated that MS significantly reduced AMSinduced HR responses in BALB/c mice when compared with control. Boophone disticha treatment significantly reduced AMS-induced BP response in BALB/c MS mice as compared to vehicle and diazepam treatments.
Conclusions: Our findings demonstrate for the first time that postnatal stress can induce short-term changes in the sensitivity of the cardiovascular system to subsequent stress which can be reduced by treatment with a freeze dried aqueous ethanolic extract of Boophone disticha. |
| format | Article |
| id | ir-11408-1675 |
| institution | My University |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | ir-11408-16752022-06-27T13:49:06Z Cardiovascular effects of Boophone disticha aqueous ethanolic extract on early maternally separated BALB/C mice Pote, William Tagwireyi, Dexter Chinyanga, Herbert M. Musara, Collin Nyandoro, George Chifamba, Jephat Nkomozepi, Pilani Boophone disticha, Maternal separation, Anxiety disorders, Blood pressure, Heart rate Ethnopharmacological relevance: There are a number of reports from traditional medical practice in Zimbabwe and neighboring countries and few in vitro studies suggesting an effect with extracts of Boophone disticha in some forms of anxiety disorder. Aim of the study: In order to validate the use of Boophone disticha in treatment of anxiety, this study was set to determine the effects of the plant extracts on blood pressure (BP) and heart rate (HR) in adult BALB/c mice subjected to repeated early maternal separation (MS) stress. Materials and methods: To test whether early life stress increases anxiety in mice, non-invasive tail cuff method was used to examine the autonomic nervous system activity by assessing cardiovascular reactivity and response to acute mixing stress (AMS) and restraint stress (RS) in adult mice subjected to early postnatal stress as compared to control. AMS-induced cardiovascular response was then evaluated in adult MS mice treated with Boophone disticha as compared to vehicle and diazepam. Results: Comparisons of the BP and HR measurements indicated that MS significantly reduced AMSinduced HR responses in BALB/c mice when compared with control. Boophone disticha treatment significantly reduced AMS-induced BP response in BALB/c MS mice as compared to vehicle and diazepam treatments. Conclusions: Our findings demonstrate for the first time that postnatal stress can induce short-term changes in the sensitivity of the cardiovascular system to subsequent stress which can be reduced by treatment with a freeze dried aqueous ethanolic extract of Boophone disticha. 2016-07-12T14:40:27Z 2016-07-12T14:40:27Z 2013 Article 0378-8741 http://hdl.handle.net/11408/1675 http://www.sciencedirect.com/science/article/pii/S0378874113001426 Journal of Ethnopharmacology;Issue 148 open Elsevier http://www.sciencedirect.com/science/article/pii/S0378874113001426 |
| spellingShingle | Boophone disticha, Maternal separation, Anxiety disorders, Blood pressure, Heart rate Pote, William Tagwireyi, Dexter Chinyanga, Herbert M. Musara, Collin Nyandoro, George Chifamba, Jephat Nkomozepi, Pilani Cardiovascular effects of Boophone disticha aqueous ethanolic extract on early maternally separated BALB/C mice |
| title | Cardiovascular effects of Boophone disticha aqueous ethanolic extract on early maternally separated BALB/C mice |
| title_full | Cardiovascular effects of Boophone disticha aqueous ethanolic extract on early maternally separated BALB/C mice |
| title_fullStr | Cardiovascular effects of Boophone disticha aqueous ethanolic extract on early maternally separated BALB/C mice |
| title_full_unstemmed | Cardiovascular effects of Boophone disticha aqueous ethanolic extract on early maternally separated BALB/C mice |
| title_short | Cardiovascular effects of Boophone disticha aqueous ethanolic extract on early maternally separated BALB/C mice |
| title_sort | cardiovascular effects of boophone disticha aqueous ethanolic extract on early maternally separated balb/c mice |
| topic | Boophone disticha, Maternal separation, Anxiety disorders, Blood pressure, Heart rate |
| url | http://hdl.handle.net/11408/1675 http://www.sciencedirect.com/science/article/pii/S0378874113001426 |
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